Qiimaha jumlada 100% saafiga ah Forsythiae Fructus Saliida naso udgoon Eucalyptus globulus

Qiimaha jumlada 100% saafiga ah Forsythiae Fructus Saliida Nasso udgoon Eucalyptus globulus Sawirka

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Forsythia suspensa(Thunb.) Vahl. (Family Oleaceae) waa geed ornamental ah, midhaha kuwaas oo loo isticmaalo sida si fiican loo yaqaan TCM "Forsythiae Fructus" (FF) (连翘in Chinese). Sifooyinka TCM ee FF waxaa lagu soo koobay dhadhan qadhaadh, oo leh dabeecad qabow khafiif ah iyo sambabada, wadnaha ama xiidmaha meridian qaybinta (Pharmacopoeia Commission of PRC, 2015), sifooyinkaas waxay barbar socdaan sifada TCM anti-bararka, sida uu qabo Chen iyo Zhang (2014). Shennong's herbal, FF waxa loo isticmaalay daawaynta pyrexia, caabuqa, jabtada, carbuncle iyo erysipelas (Cho et al., 2011). Laba nooc oo FF ah ayaa diyaar ah, midhaha bislaaday ee cagaarka ah ee cusub ee loo yaqaan "Qingqiao" iyo mid si buuxda u bislaaday oo la yiraahdo "Laoqiao". Labaduba waxay u adeegaan sida ilaha rasmiga ah ee FF, si kastaba ha ahaatee, Qingqiao waxaa si joogta ah loogu isticmaalaa daawooyinka TCM (Jia et al., 2015). Meelaha ugu waaweyn ee wax soo saarka ee FF waa Hebei, Shaanxi, Shanxi, Shandong, Anhui, Henan, Hubei, Jiangsu (beeray) iyo Sichuan Provinces (Guddiga Tafatirka ee Flora ee Shiinaha, 1978).

Daabacaadda 2015-ka Shiinaha ee Pharmacopoeia, 114 diyaargarowga dawooyinka Shiinaha oo ay ku jiraan FF ayaa ku taxan, sida Shuanghuanglian xalalka afka ah, Kiniinka Yinqiao Jiedu, Kiniinka Niuhuang Shangqing, iwm (Guddiga Farmashiyaha ee PRC, 2015). Cilmi-baarisyada casriga ahi waxay muujinayaan anti-bararka (Kim et al., 2003), antioxidant (CC Chen et al., 1999), bakteeriyada (Han et al., 2012), anti-kansarka (Hu et al., 2007), anti-bararka. -virus (Ko et al., 2005), anti-xasaasiyadda (Hao et al., 2010), neuroprotective (S. Zhang et al., 2015) saamaynta,iwm.In kasta oo midhaha kaliya loo isticmaalo sida TCM, cilmi-baadhisyada qaarkood ayaa sheegay phytochemistry iyo saamaynta dawooyinka ee caleemaha (Ge et al., 2015, Zhang et al., 2015), ubax (Takizawa et al., 1981) iyo miraha (Zhang et al. ., 2002) eeF. suspensa. Sidaa darteed, waxaan hadda bixinaa dulmar nidaamsan oo ku saabsan macluumaadka la heli karo eeF. suspensa, oo ay ku jiraan isticmaalka dhaqameed, botany, phytochemistry, farmashiyaha, sunta, farmashiyaha iyo ilaalinta tayada. Sidoo kale, tilmaamaha mustaqbalka ee cilmi-baarista ayaa laga wada hadlay.

Qaybo goos goos ah

Adeegsiga dhaqanka

Qoraallada dhirta ee Shiinaha ee qadiimiga ah, FF waxaa loo diiwaan geliyay inay faa'iido u leedahay daawaynta fistula jiirka, scrofula, carbuncle, boog xun, buro xameeti, kulayl iyo sun (Shennong's herbal, Bencao Chongyuan, Bencao Zhengyi, Zhenglei Bencao). Sida laga soo xigtay qaar badan oo qadiimi ah, geedo caafimaadeedkan ayaa si aad ah waxtar ugu leh nadiifinta kulaylka kanaalka wadnaha iyo sii daynta qoyaanka- kulaylka beeryarada iyo caloosha. Waxa kale oo ay daawayn u tahay daawaynta stranguria, bararka, fadhiista qi iyo fadhiidnimada dhiiga

dhirta

F. suspensa(Weeping Forsythia) waa geed go'an oo qurxin ah oo u dhashay Shiinaha, koraya ilaa 3 m (Jaantus. 1). Waxay leedahay internodes godan oo leh laamo fidsan ama fidsan kuwaas oo ah midab huruud-brown ama cawl-brown. Caleemaha badanaa waa sahlan yihiin, laakiin mararka qaarkood 3-foliolate. Caleemaha caleenku waa ugxan, barar ballaaran, ama elliptik-ovate iyo 2-10 × 1.5-5 cm2 oo cabbir ah oo leh saldhig wareegsan ilaa cufan iyo cirif ba'an. Labada dhinac ee caleemuhu waa cagaar, dhalaal leh oo si adag u leh ama si qotodheer leh

Phytochemistry

Maalmahan, 237 xeryood ayaa laga helayF. suspensa, oo ay ku jiraan 46 lignans (1-46), 31 phenylethanoid glycosides (47-77), 11 flavonoids (78-88), 80 terpenoids (89-168), 20 cyclohexylethanol derivatives (169-188), lix alkaloids (189) ), afar steroids (195-198) iyo 39 xeryahooda kale (199-237). Waxaa ka mid ah, laba qaybood (21-22) ayaa laga soocay ubaxyadaF. suspensa, 19 qaybood (94-100, 107-111, 115-117, 198, 233-235) ayaa laga soocay caleemahaF. suspensa, afar qaybood

Saamaynta anti-bararka

Hawlaha ka hortagga bararka ee FF waxay taageertaa saameynteeda nadiifinta kulaylka (Guo et al., 2015). Caabuqa waa jawaab-celin jireed oo ku wajahan kicinta caabuqa, xasaasiyadda, ama kiimikada (Lee et al., 2011). Waxay ku hawlan tahay horumarinta cudurrada daba-dheeraada, sida cudurrada maqaarka, xasaasiyadda, iyo kansarka;iwm.FF waa mid ka mid ah TCM oo leh awood xoog leh oo ka-hortagga bararka, si weyn ayaa loogu dabaqaa bararka daba-dheeraada iyo ba'an. Dhaqdhaqaaqyada ka hortagga bararka ee FF ayaa kaalinta shanaad ka galay 81 la tijaabiyey TCM (70% ethanol

Sunta

Ilaa hadda, ma jiro warbixin ku saabsan sunta FF. Qiyaasta maamulka maalinlaha ah ee FF ayaa la soo jeediyay inay noqoto 6-15 g (Guddiga Farmacopoeia ee PRC, 2015). Warbixinada laxidhiidha ayaa tilmaamay in aanay jirin sunta biyaha ama ethanol laga soosaaray caleemahaF. suspensajiirarka, xitaa qiyaasta maalinlaha ah ee 61.60 g/kg (Ai et al., 2011, Hou et al., 2016, Li et al., 2013). Han iyo al. (2017) ma sheegin sunta daran ee phillyrin (laga bilaabo caleemahaF. suspensa)gudaha jiirarka NIH (18.1 g/kg/maalintii, po, muddo 14 maalmood ah) ama maya

Farmashiyaha

Li iyo al. lagu aqoonsaday sagaal waji oo dheef-shiid kiimikaad ee phillyrin ee muunadaha kaadida ee jiirka oo soo bandhigay dariiqooyinkooda dheef-shiid kiimikaad ee jiirka. Phillyrin waxaa markii hore loo rogay phillygenin ka dibna loo beddelay dheef-shiid kiimikaad kale iyada oo loo marayo methylation, demethylation, fuuq-baxa iyo hababka furitaanka giraanta (Li et al., 2014c). H. Wang iyo al. (2016) ayaa aqoonsaday 34 wejiga I iyo wajiga II dheef-shiid kiimikaad ee phillyrin wuxuuna tilmaamay in hydrolysis, oxidation iyo sulfation ay ahaayeen kuwo waaweyn.

Xakamaynta tayada

Si loo xakameeyo tayada FF, Pharmacopoeia Shiinaha waxay soo jeedinaysaa morphological, microscopic iyo aqoonsiga TLC marka lagu daro go'aaminta HPLC. Muunada FF ee u qalma waa inay ka kooban yihiin wax ka badan 0.150% phillyrin (Guddiga Farmashiyaha ee PRC, 2015).

Si kastaba ha ahaatee, hal calaamad oo tiro ah, phillyrin, ayaa u muuqata mid aan ku filnayn in lagu qiimeeyo tayada FF. Dhawaan, qaybo kala duwan oo bioactive ah oo ku jira FF ayaa lagu baadhay chromatography gaar ah, electrophoresis, MS iyo hababka NMR, sida

Gabagabo iyo aragtiyaha mustaqbalka

Dib-u-eegga hadda socda ayaa soo koobaya macluumaad dhammaystiran oo ku saabsan isticmaalka dhaqameed, botany, phytochemistry, saamaynta dawooyinka, sunta, farmashiyaha iyo xakamaynta tayadaF. suspensa. Qoraalada dhirta qadiimiga ah ee Shiinaha iyo Pharmacopoeia ee Shiinaha, FF waxaa inta badan loo isticmaalaa nadiifinta kulaylka iyo sunta. Ilaa hadda, in ka badan 230 xeryood ayaa la kala saaray oo laga aqoonsaday geedo yaryar. Waxaa ka mid ah, lignans iyo phenylethanoid glycosides waxaa loo tixgeliyaa inay yihiin sifo iyo bioactive.

Qeexitaannada TCM

Yin: "Yin" waa mid ka mid ah labada awoodood ee dabiiciga ah ee iskaashanaya, marka loo eego dhismihii hore ee Shiinaha ee caalamka. "Yin" waxaa lagu gartaa mid gaabis ah, jilicsan, wax soo saar leh, fidsan, qabow, qoyan ama xasilloon, waxayna la xiriirtaa biyaha, dhulka, dayaxa, dheddigga iyo habeenkii.

Qi: Ereyada acupuncture, "qi" waa "xoogga nolosha". Waa isha dhammaan dhaqdhaqaaqa jidhka, ka hortagga duulaanka jidhka, isha dhammaan hawlaha dheef-shiid kiimikaadka, waxay siisaa haynta unugyada.

Mahadnaq

Shaqadan waxaa taageeray Mashruuca Wadajirka ah ee Cilmi-baarista Sayniska ee Beijing oo leh waxbarashada dib-u-dhigista-Cilmi-baarista tignoolajiyada muhiimka ah iyo adeegsiga qiimeynta badbaadada ee agabka dawooyinka Shiinaha ee sunta ah ee ku saleysan isku dhafka kiimikada iyo astaamaha zebrafish.

Qiimaha FOB:US $0.5 - 9,999 / Qayb

Tirada Dalbashada Min.100 Qaybood/Qeyb

Awooda wax bixinta:10000 Qeybaha/Qeybaha bishii

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Ethnopharmacological ku habboonaanta

Forsythiae Fructus (loo yaqaan Lianqiao ee Shiinaha), midhahaForsythia suspensa(Thunb.) Vahl, waxaa looga isticmaalaa dawo dhaqameed caadi ah Shiinaha, Japan iyo Kuuriya. Waxaa dhaqan ahaan loo isticmaalaa in lagu daweeyo pyrexia, bararka,jabtada,carbuncleiyoerysipelas. Iyada oo ku xidhan wakhtiga goosashada ee kala duwan, Forsythiae Fructus waxa loo kala saari karaa laba nooc, oo kala ah Qingqiao iyo Laoqiao. Miraha cagaarka ah ee bilaaba inay bislaadaan waxa loo soo ururiyaa sida Qingqiao, halka midhaha jaalaha ah ee si buuxda u bislaaday loo ururiyo sidii Laoqiao. Labadaba waxaa lagu dabaqaa isticmaalka caafimaadka. Dib-u-eegiddu waxay ujeeddadeedu tahay inay bixiso soo koobid habaysanF. suspensa(Forsythia suspensa(Thunb.) Vahl) iyo in la muujiyo xidhiidhka ka dhexeeya isticmaalka dhaqameed iyohawlaha dawooyinkasi ay u bixiyaan dhiirigelin cilmi-baarista mustaqbalka.

Qalabka iyo hababka

Dhammaan macluumaadka u dhigma ee ku saabsanF. suspensawaxaa baadhay Scifinder oo laga helay xog-ururinta sayniska oo ay ku jiraan Springer, Science Direct, Wiley, Pubmed iyo China Knowledge Resource Integrated (CNKI). Buugaag iyo qoraallo maxalli ah ayaa sidoo kale la baadhay.

Natiijooyinka

Sida laga soo xigtay qoraalada dhirta qadiimiga ah ee Shiinaha iyo Pharmacopoeia Shiinaha, Forsythiae Fructus waxay si weyn u muujisaa nadiifinta kulaylka iyo sunta suntaTCMdawooyinka. Cilmi-baadhis casri ah, in ka badan 230 xeryood ayaa la kala saaray oo laga aqoonsadayF. suspensa. 211 Oo iyaga ka mid ah ayaa laga soocay midhaha.Lignansiyo phenylethanoidsglycosidesWaxa loo tixgaliyaa inay yihiin sifada iyo walxaha firfircoon ee geedo yaryar, sida forsythiaside, phillyrin,rutiniyo phillygenin. Waxay soo bandhigeen anti-bararka, antioxidant, bakteeriyada, anti-virus, anti-kansarka iyo saamaynta xasaasiyadda,iwm.Hadda, ma jirto warbixin ku saabsan sunta Forsythiae Fructus, in kasta oo sun yar oo forsythiaside lagu sheegay daabacaadyada maxalliga ah. Marka la barbardhigo Laoqiao, Qingqiao waxa ku jira heerar sare oo forsythiaside ah, forsythoside C, cornoside,rutin, phillyrin,gallic acidiyochlorogenic acidiyo heerarka hoose ee rengyol,β-glucose iyo S-supensasidemethyl ether.

Gabagabo

Ficilada kulaylka nadiifinta ee Forsythiae Fructus waxay ku saleysan yihiin sifooyinka anti-bararka iyo antioxidant ee lignans iyo phenylethanoid.glycosides. Saamaynta sunta-ka-soo-saarka ayaa loo aaneynayaa bakteeriyada, fayraska iyo ka hortagga kansarka ee Forsythiae Fructus. Iyo astaamaha dawooyinka dhaqameed ee Shiinaha (TCM) ee Forsythiae Fructus (dhadhan qadhaadh, dabeecad yar oo qabow iyo meeris sambabada) ayaa taageeray saameynteeda xooggan ee ka hortagga bararka. Intaa waxaa dheer, anti-bararka cajiib ah iyoawoodaha antioxidantForsythiae Fructus waxay gacan ka geysataa ka hortagga kansarka iyoneuroprotectivehawlaha. Qaybta sare ee lignans iyo phenylethanoid glycosides ee Qingqiao marka loo eego Laoqiao waxay sharxi kartaa awoodda antioxidant ee wanaagsan ee Qingqiao iyo isticmaalka joogtada ah ee QingqiaoTCMdawooyinka. Cilmi-baarista mustaqbalka, wax badanin vivotijaabooyinka iyo daraasadaha kiliinikada ayaa lagu dhiirigelinayaa inay sii caddeeyaan xidhiidhka ka dhexeeya isticmaalka dhaqameed iyo codsiyada casriga ah. Marka laga hadlayo Qingqiao iyo Laoqiao, waxay ku sii jirayaan in lagu kala saaro hababka xakamaynta tayada oo dhan, iyo isku dhafka kiimikada iyo saameynta caafimaad ee dhexdooda waa in la barbardhigo.