Magnolia dabiiciga ah ee dabiiciga ah ee lagama maarmaanka ah saliidda magnoliae saliidda saliidda cadarka

Magnolia dabiiciga ah ee dabiiciga ah ee lagama maarmaanka u ah saliidda magnoliae saliidda cadarka Sawirka

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Magnoliae Flos waa daawo dhaqameed inta badan laga isticmaalo Aasiya. Waxa loo isticmaalaa in lagu daweeyo sinusitis, sanka oo xidhma, iyo maqaarka xasaasiga ah. Sababtoo ah Magonlia Flos waxaa lagu tilmaamay inay tahay walxo udgoon qoraaladii hore ee Shiinaha, waxaanu ku qiyaasnay in saliideeda lagama maarmaanka ah loo isticmaali karo in lagu daweeyo xanuunada difaaca. Unugyada Dendritic (DCs), oo loo arko inay yihiin bartilmaameedka ugu weyn ee immunomodulators si loo xakameeyo jawaabaha difaaca jirka, ayaa door muhiim ah ka ciyaara jawaabta la qabsiga difaaca. Daraasaddan, Magnoliae Flos saliidda muhiimka ah (MFEO) waxay hoos u dhigtay wax soo saarka cytokines TNF-a, IL-6, iyo IL-12p70 ee lipopolysaccharide (LPS) -kicinta DCs. Waxa kale oo ay xakamaysay calaamadaha dusha MHC II, CD80, iyo CD86 ee LPS-kicinta DC-yada. Moodooyinka xayawaanku waxay muujiyeen in 2,4-Dinitro-1-fluorobenzene (DNFB) oo keenaysa jawaab-celin xasaasiyadeed oo xiriir ah ayaa la joojiyay ka dib daaweynta MFEO. Intaa waxaa dheer, MFEO waxay joojisay galitaanka unugyada T ee dhegaha jiirarka DNFB. Si loo sahamiyo xeryahooda bioactive, qaybaha MFEO ayaa lagu falanqeeyay iyadoo la adeegsanayo gaaska chromatography (GC) iyo GC-mass spectrometry. Natiijooyinka ayaa shaaca ka qaaday in xeryahooda waaweyn ee MFEO ay yihiin camphor iyo 1,8-cineole. Baaritaanno dheeri ah oo DC ah ayaa xaqiijiyay in isku-dhafkan ay si weyn u xakameeyeen wax soo saarka cytokine ee LPS-ku-abuuray DC-yada. Sidaa darteed, waxaan muujinnay in MFEO ay muujiso saameyn difaac difaac ah labadaba gudaha vivo iyo in vitro, iyo camphor iyo 1,8-cineole waxay noqon karaan qaybaha ugu waaweyn ee mas'uul ka ah awooddeeda difaac. Natiijooyinka ayaa tilmaamaya in MFEO ay awood u leedahay in loo horumariyo sidii difaac cusub oo loogu talagalay cudurrada xad-dhaafka ah.

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, IL-6, iyo IL-12p70 ee lipopolysaccharide (LPS) -dhaqaale DC-yada. Waxa kale oo ay xakamaysay calaamadaha dusha MHC II, CD80, iyo CD86 ee LPS-kicinta DC-yada. Moodooyinka xayawaanku waxay muujiyeen in 2,4-Dinitro-1-fluorobenzene (DNFB) oo keenaysa jawaab-celin xasaasiyadeed oo xiriir ah ayaa la joojiyay ka dib daaweynta MFEO. Intaa waxaa dheer, MFEO waxay joojisay galitaanka unugyada T ee dhegaha jiirarka DNFB. Si loo sahamiyo xeryahooda bioactive, qaybaha MFEO ayaa lagu falanqeeyay iyadoo la adeegsanayo gaaska chromatography (GC) iyo GC-mass spectrometry. Natiijooyinka ayaa shaaca ka qaaday in xeryahooda waaweyn ee MFEO ay yihiin camphor iyo 1,8-cineole. Baaritaanno dheeri ah oo DC ah ayaa xaqiijiyay in isku-dhafkan ay si weyn u xakameeyeen wax soo saarka cytokine ee LPS-ku-abuuray DC-yada. Sidaa darteed, waxaan soo bandhignay in MFEO ay muujiso saameyn difaac difaac ah labadabain vivoiyoin vitro, iyo camphor iyo 1,8-cineole ayaa laga yaabaa inay yihiin qaybaha ugu waaweyn ee ka masuulka ah awoodeeda difaac. Natiijooyinka ayaa tilmaamaya in MFEO ay awood u leedahay in loo horumariyo sidii difaac cusub oo loogu talagalay cudurrada xad-dhaafka ah.