Xidhmada Custom OEM Saliida Macrocephalae Dabiiciga ah ee Rhizoma

sharaxaad gaaban:

Sida wakiilka kiimikaad wax ku ool ah, 5-fluorouracil (5-FU) ayaa si weyn loogu codsadaa daaweynta burooyinka halista ah ee mareenka caloosha iyo mindhicirka, madaxa, qoorta, laabta, iyo ugxansidaha. Iyo 5-FU waa dawada safka kowaad ee kansarka mindhicirka ee rugta caafimaadka. Habka ficilka ee 5-FU waa in la xannibo isbeddelka uracil nucleic acid ee loo yaqaan 'thymine nucleic acid' ee unugyada burooyinka, ka dibna waxay saameeyaan isku-dhafka iyo hagaajinta DNA iyo RNA si loo gaaro saameynteeda cytotoxic (Afzal et al., 2009; Ducreux et al. al., 2015; Longley iyo al., 2003). Si kastaba ha noqotee, 5-FU waxay sidoo kale soo saartaa shubanka-kimoterabiga-ku-daaweynta (CID), mid ka mid ah fal-celinta xun ee ugu badan ee ku dhacda bukaanno badan (Filho et al., 2016). Dhacdooyinka shubanka ee bukaanada lagu daaweeyay 5-FU waxay ahaayeen ilaa 50%-80%, taas oo si xun u saamaysay horumarka iyo waxtarka daaweynta kemotherabi (Iacovelli et al., 2014; Rosenoff et al., 2006). Sidaa darteed, waa muhiimad muhiim ah in la helo daawayn wax ku ool ah oo loogu talagalay 5-FU ee CID-da.

Waqtigan xaadirka ah, waxqabadyo aan daroogo ahayn iyo waxqabadyo daroogo ayaa loo soo dhoofiyay daawaynta kiliinikada ee CID. Waxqabadyada aan dawada ahayn waxaa ka mid ah cunto macquul ah, oo lagu daro milix, sonkor iyo nafaqooyin kale. Daawooyinka sida loperamide iyo octreotide ayaa caadi ahaan loo isticmaalaa daawaynta ka hortagga shubanka ee CID (Benson et al., 2004). Intaa waxaa dheer, ethnomedicines ayaa sidoo kale loo qaatay in lagu daaweeyo CID iyaga oo wata daawayn u gaar ah dalal kala duwan. Daawo dhaqameed Shiinees ah (TCM) waa mid ka mid ah ethnomedicine caadiga ah oo lagu dhaqmi jiray in ka badan 2000 sano wadamada Bariga Aasiya oo ay ku jiraan Shiinaha, Japan iyo Kuuriya (Qi et al., 2010). TCM waxay haysaa in dawooyinka kiimikaad ay kicinayaan isticmaalka Qi, yaraanta beeryarada, calool xumada iyo qoyaanka endophytic, taas oo keenta cillad la'aanta xiidmaha. Aragtida TCM, istaraatijiyadda daawaynta ee CID waa in ay inta badan ku xidhan tahay kabidda Qi iyo xoojinta beeryarada (Wang et al., 1994).

Xididdada engegan eeAtractylodes macrocephalaKoidz (AM) iyoPanax ginsengCA Mey. (PG) waa daawooyinka dhirta caadiga ah ee TCM oo leh saameyn isku mid ah kaabista Qi iyo xoojinta beeryarada (Li et al., 2014). AM iyo PG ayaa inta badan loo isticmaalaa sidii lammaane geedo ah (qaabka ugu fudud ee ku habboon geedaha Shiinaha) oo leh saamaynta kordhinta Qi iyo xoojinta beeryarada si loo daweeyo shubanka. Tusaale ahaan, AM iyo PG waxaa lagu diiwaan geliyay hababka caadiga ah ee ka hortagga shubanka sida Shen Ling Bai Zhu San, Si Jun Zi TangTaiping Huimin Heji Ju Fang(Boqortooyada Heesaha, Shiinaha) iyo Bu Zhong Yi Qi Tang oo ka socdaPi Wei Lun( Boqortooyada Yuan, Shiinaha) (Jaantus. 1). Daraasado dhowr ah oo hore ayaa soo sheegay in dhammaan saddexda qaacido ay leeyihiin awoodda yareynta CID (Bai et al., 2017; Chen et al., 2019; Gou et al., 2016). Intaa waxaa dheer, daraasaddeennii hore waxay muujisay in Shenzhu Capsule oo ka kooban AM iyo PG oo keliya ay saameyn ku yeelan karaan daaweynta shubanka, colitis (xiexie syndrome), iyo cudurrada kale ee caloosha iyo mindhicirka (Feng et al., 2018). Si kastaba ha ahaatee, ma jirto daraasad ka hadashay saameynta iyo habka AM iyo PG ee daaweynta CID, haddii la isku daro ama kaligiis.

Hadda mindhicirka microbiota waxaa loo arkaa inay tahay arrin suurtagal ah oo lagu fahmi karo habka daaweynta ee TCM (Feng et al., 2019). Daraasadaha casriga ah waxay muujinayaan in microbiota mindhicirku uu door muhiim ah ka ciyaaro ilaalinta homeostasis xiidmaha. Microbiota mindhicirka caafimaad qaba waxay gacan ka geysataa ilaalinta xuubka mindhicirka, dheef-shiid kiimikaadka, homeostasis-ka difaaca jirka iyo jawaabta, iyo xakamaynta cudur-sidaha (Thursby iyo Juge, 2017; Pickard et al., 2017). Microbiota mindhicirka ee cilladaysan waxay wax u dhimaysaa hawlaha jir ahaaneed iyo difaaca jidhka bini'aadamka si toos ah ama si aan toos ahayn, taasoo keenta dareen-celinta dhinaca sida shubanka (Patel et al., 2016; Zhao iyo Shen, 2010). Cilmi-baaristu waxay muujisay in 5-FU ay si cajiib ah u beddeshay qaabka microbiota mindhicirka ee jiirarka shubanka (Li et al., 2017). Sidaa darteed, saameynta AM iyo PM ee shubanka 5-FU waxaa dhexdhexaadin kara microbiota mindhicirka. Si kastaba ha ahaatee, haddii AM iyo PG keligood iyo isku darka ay ka hortagi karaan shuban 5-FU ah iyadoo la bedelayo microbiota mindhicirka weli lama garanayo.

Si loo baadho saamaynta shubanka ka hortagga iyo habka hoose ee AM iyo PG, waxaanu isticmaalnay 5-FU si aanu ugu sawirno qaabka shubanka ee jiirarka. Halkan, waxaanu diirada saarnay saamaynta iman karta ee maamulka kali iyo isku-dhafka ah (AP) eeAtractylodes macrocephalasaliida lagama maarmaanka ah (AMO) iyoPanax ginsengwadarta saponins (PGS), qaybaha firfircoon ee siday u kala horreeyaan laga soo saaray AM iyo PG, shubanka, cudurada mindhicirka iyo qaabdhismeedka microbial ka dib 5-FU kiimoterabi.